RRC ID 69774
著者 Inoue M, Horiuchi K, Susa M, Taguchi E, Ishizaka T, Rikitake H, Matsuhashi Y, Chiba K.
タイトル Trabectedin suppresses osteosarcoma pulmonary metastasis in a mouse tumor xenograft model.
ジャーナル J Orthop Res
Abstract Osteosarcoma (OS) is the most common primary bone tumor that mainly affects adolescents and young adults. Although standard treatment modality can achieve up to 60%-70% 5-year survival rate, there has not been any substantial improvement over the past four decades. Furthermore, those presenting with pulmonary metastatic lesions often undergo a highly unfavorable clinical course. Therefore, there is a severely unmet clinical need to provide a more effective treatment for patients with OS. In this study, we show that trabectedin (TBD), a chemotherapeutic agent approved for soft tissue sarcomas, significantly suppresses pulmonary metastasis in a mouse OS xenograft model. In vitro experiments revealed that TBD suppresses cell migration potentially by downregulating the activity of ERK1/2, intracellular molecules that are critically involved in the regulation of cell motility. Collectively, our data may provide a basis for further investigation of TBD on the potential use for OS patients who are at great risk of pulmonary metastasis.
巻・号 40(4)
ページ 945-953
公開日 2022-4-1
DOI 10.1002/jor.25105
PMID 34057747
MeSH Adolescent Animals Bone Neoplasms* / drug therapy Bone Neoplasms* / pathology Cell Line, Tumor Cell Movement Cell Proliferation Disease Models, Animal Heterografts Humans Lung Neoplasms* / pathology Mice Neoplasm Metastasis Osteosarcoma* / drug therapy Osteosarcoma* / pathology Trabectedin / therapeutic use
IF 2.728
リソース情報
ヒト・動物細胞 LM8(RCB1450)