論文 - 詳細
| RRC ID | 69843 |
|---|---|
| 著者 | Auer S, Hable V, Greubel C, Drexler GA, Schmid TE, Belka C, Dollinger G, Friedl AA. |
| タイトル | Survival of tumor cells after proton irradiation with ultra-high dose rates. |
| ジャーナル | Radiat Oncol |
| Abstract |
BACKGROUND:Laser acceleration of protons and heavy ions may in the future be used in radiation therapy. Laser-driven particle beams are pulsed and ultra high dose rates of >10⁹ Gy s⁻¹ may be achieved. Here we compare the radiobiological effects of pulsed and continuous proton beams. METHODS:The ion microbeam SNAKE at the Munich tandem accelerator was used to directly compare a pulsed and a continuous 20 MeV proton beam, which delivered a dose of 3 Gy to a HeLa cell monolayer within < 1 ns or 100 ms, respectively. Investigated endpoints were G2 phase cell cycle arrest, apoptosis, and colony formation. RESULTS:At 10 h after pulsed irradiation, the fraction of G2 cells was significantly lower than after irradiation with the continuous beam, while all other endpoints including colony formation were not significantly different. We determined the relative biological effectiveness (RBE) for pulsed and continuous proton beams relative to x-irradiation as 0.91 ± 0.26 and 0.86 ± 0.33 (mean and SD), respectively. CONCLUSIONS:At the dose rates investigated here, which are expected to correspond to those in radiation therapy using laser-driven particles, the RBE of the pulsed and the (conventional) continuous irradiation mode do not differ significantly. |
| 巻・号 | 6 |
| ページ | 139 |
| 公開日 | 2011-10-18 |
| DOI | 10.1186/1748-717X-6-139 |
| PII | 1748-717X-6-139 |
| PMID | 22008289 |
| PMC | PMC3215966 |
| MeSH | Apoptosis Cell Cycle Cell Survival Flow Cytometry HeLa Cells Heavy Ions Humans Ions Lasers Microscopy, Fluorescence / methods Neoplasms / pathology Neoplasms / radiotherapy* Particle Accelerators Protons Radiotherapy / methods Relative Biological Effectiveness Time Factors X-Rays |
| IF | 2.817 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 30 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 3.0 |
| リソース情報 | |
| ヒト・動物細胞 | HeLa(RCB0007) |