論文 - 詳細
| RRC ID | 69852 |
|---|---|
| 著者 | Ishikawa T, Saito T, Kurosawa A, Watanabe T, Maruyama S, Ichikawa Y, Yamada R, Okuzawa H, Sato H, Ueno K. |
| タイトル | 2-Aryl-1,4-naphthoquinone-1-oxime methyl ethers: their cytotoxic activity. |
| ジャーナル | Chem Pharm Bull (Tokyo) |
| Abstract |
Preliminary examination for the structure-activity relationship of quinone monooxime derivatives on cytotoxicity against HeLa S3 cell and further trials using eight different cell lines suggested that 2-aryl-6,7-methylenedioxy-1,4-naphthoquinone-1-oxime methyl ethers, carrying 2-methoxy-4,5-methylenedioxyphenyl, 7-methoxy-2-methylbenzofuran-4-yl, and 2-methoxycarbonyl-3,4-dimethoxyphenyl as the 2-aryl substituent, were potential candidates for anti-cancer drugs. |
| 巻・号 | 59(4) |
| ページ | 472-5 |
| 公開日 | 2011-1-1 |
| DOI | 10.1248/cpb.59.472 |
| PII | JST.JSTAGE/cpb/59.472 |
| PMID | 21467676 |
| MeSH | Antineoplastic Agents / chemistry* Antineoplastic Agents / isolation & purification Antineoplastic Agents / toxicity Cell Line, Tumor Drug Screening Assays, Antitumor Humans Methyl Ethers / chemistry* Naphthoquinones / chemistry* Naphthoquinones / toxicity Oximes / chemistry* Oximes / toxicity Structure-Activity Relationship |
| IF | 1.416 |
| リソース情報 | |
| ヒト・動物細胞 | HeLa(RCB0007) |