RRC ID 69869
Author Nomura S, Kono R, Imaoka M, Tazaki F, Okuno Y, Utsunomiya H, Takeda M, Nakamura M.
Title Traditional Japanese apricot (Prunus mume) induces osteocalcin in osteoblasts.
Journal Biosci Biotechnol Biochem
Abstract The fruit of Prunus mume (ume, also known as Japanese apricot) has been used as a functional food in Japan since ancient times. We previously reported that ume stimulates the differentiation of preosteoblastic cells. Osteocalcin (OCN) is secreted by osteoblasts, and there is known association with glucolipid metabolism and cognitive function. This study sought to clarify the relationship between ume extracts and OCN production both in vitro and in vivo. Alkaline phosphatase activity and OCN level in the ethyl acetate extracts of ume-treated extracts were significantly increased in preosteoblast MC3T3-E1 cells compared with the control group. In human study, serum OCN level was significantly higher in the high ume intake group than in the low intake group in community-dwelling participants over 60 years old. These results suggest that ume has the potential to upregulated OCN production both in vitro and in vivo.
Volume 86(4)
Pages 528-534
Published 2022-3-21
DOI 10.1093/bbb/zbac013
PII 6527568
PMID 35150233
MeSH Fruit / metabolism Humans Middle Aged Osteoblasts / metabolism Osteocalcin / genetics Plant Extracts / metabolism Plant Extracts / pharmacology Prunus* Prunus armeniaca*
IF 1.516
Resource
Human and Animal Cells MC3T3-E1(RCB1126)