| RRC ID |
69881
|
| 著者 |
Pham DN, Hiromoto S, Yamazaki T, O M, Kobayashi E.
|
| タイトル |
Enhanced Corrosion Resistance and In Vitro Biocompatibility of Mg-Zn Alloys by Carbonate Apatite Coating.
|
| ジャーナル |
ACS Appl Bio Mater
|
| Abstract |
B-type carbonate apatite (CAp) coatings were formed on as-cast and T4-treated Mg-xZn (x = 1, 5, and 7 wt %) alloys containing various sized Zn-rich second phase to improve the corrosion resistance and biocompatibility. The CAp coating grew uniformly on the alloys with a thickness of 1.1-1.3 μm and did not show cracks or pores on 30 μm-sized second-phase particles. The CAp coating retarded corrosion of Mg-Zn substrates for the first 3-5 days in Hanks' solution. Polarization resistance of the CAp-coated alloys was 10-90 and 1-70 times higher than the uncoated and hydroxyapatite (HAp)-coated alloys, respectively. The corrosion rate of CAp-coated alloys was greatly affected by the substrate alloys once the coatings were partly broken. The CAp-coated alloys showed 40-60 and 25-45% lower 14-day average corrosion rates than the uncoated and HAp-coated alloys, respectively, in the immersion test. The CAp coating significantly enhanced the viability of osteoblastic MC3T3-E1 cells on the Mg-Zn alloys for 72 h compared to the uncoated and HAp-coated alloys. The cell densities on CAp-coated alloys were similar for 72 h regardless of substrate alloys. Therefore, the CAp coating can be a superior coating candidate for corrosion-control and biocompatibility improvement for biodegradable Mg alloys.
|
| 巻・号 |
4(9)
|
| ページ |
6881-6892
|
| 公開日 |
2021-9-20
|
| DOI |
10.1021/acsabm.1c00594
|
| PMID |
35006988
|
| MeSH |
Alloys* / pharmacology
Apatites
Coated Materials, Biocompatible* / pharmacology
Corrosion
Durapatite / pharmacology
Zinc
|
| リソース情報 |
| ヒト・動物細胞 |
MC3T3-E1(RCB1126) |
