| RRC ID |
69920
|
| Author |
Natsume N, Ozaki K, Nakajima D, Yokoshima S, Teruya T.
|
| Title |
Structure-Activity Relationship Study of Majusculamides A and B and Their Analogues on Osteogenic Activity.
|
| Journal |
J Nat Prod
|
| Abstract |
We discovered that majusculamide A (1) and majusculamide B (2), isolated from a marine cyanobacterium collected in Okinawa, induced osteoblast differentiation in MC3T3-E1 cells. Although majusculamide A (1) has a different configuration only at the C-19 stereocenter, bearing a methyl group, compared to majusculamide B (2), the effect of 1 was stronger than that of 2. We synthesized some analogues of the majusculamides (3-15) and evaluated osteogenic activities of these analogues. The structure-activity relationship study of majusculamide analogues suggested that the number of methyls and configuration at C-19 and the nature of the substituent at C-20 of majusculamide A (1) may be important for the osteoblast differentiation-inducing effect of 1.
|
| Volume |
83(8)
|
| Pages |
2477-2482
|
| Published |
2020-8-28
|
| DOI |
10.1021/acs.jnatprod.0c00441
|
| PMID |
32786886
|
| MeSH |
3T3 Cells
Animals
Cell Differentiation / drug effects
Mice
Osteogenesis / drug effects*
Structure-Activity Relationship
|
| IF |
3.782
|
| Resource |
| Human and Animal Cells |
MC3T3-E1(RCB1126) |
