RRC ID |
69939
|
著者 |
Wandel MB, Bell CA, Yu J, Arno MC, Dreger NZ, Hsu YH, Pitto-Barry A, Worch JC, Dove AP, Becker ML.
|
タイトル |
Concomitant control of mechanical properties and degradation in resorbable elastomer-like materials using stereochemistry and stoichiometry for soft tissue engineering.
|
ジャーナル |
Nat Commun
|
Abstract |
Complex biological tissues are highly viscoelastic and dynamic. Efforts to repair or replace cartilage, tendon, muscle, and vasculature using materials that facilitate repair and regeneration have been ongoing for decades. However, materials that possess the mechanical, chemical, and resorption characteristics necessary to recapitulate these tissues have been difficult to mimic using synthetic resorbable biomaterials. Herein, we report a series of resorbable elastomer-like materials that are compositionally identical and possess varying ratios of cis:trans double bonds in the backbone. These features afford concomitant control over the mechanical and surface eroding degradation properties of these materials. We show the materials can be functionalized post-polymerization with bioactive species and enhance cell adhesion. Furthermore, an in vivo rat model demonstrates that degradation and resorption are dependent on succinate stoichiometry in the elastomers and the results show limited inflammation highlighting their potential for use in soft tissue regeneration and drug delivery.
|
巻・号 |
12(1)
|
ページ |
446
|
公開日 |
2021-1-19
|
DOI |
10.1038/s41467-020-20610-5
|
PII |
10.1038/s41467-020-20610-5
|
PMID |
33469013
|
PMC |
PMC7815890
|
MeSH |
3T3 Cells
Absorbable Implants*
Animals
Biocompatible Materials / chemistry*
Cell Line
Elastomers
Female
Humans
Materials Testing
Mesenchymal Stem Cells
Mice
Polymerization
Rats
Stereoisomerism
Surface Properties
Tensile Strength
Tissue Engineering / methods*
Tissue Scaffolds / chemistry*
|
IF |
12.121
|
リソース情報 |
ヒト・動物細胞 |
MC3T3-E1(RCB1126) |