RRC ID 69939
著者 Wandel MB, Bell CA, Yu J, Arno MC, Dreger NZ, Hsu YH, Pitto-Barry A, Worch JC, Dove AP, Becker ML.
タイトル Concomitant control of mechanical properties and degradation in resorbable elastomer-like materials using stereochemistry and stoichiometry for soft tissue engineering.
ジャーナル Nat Commun
Abstract Complex biological tissues are highly viscoelastic and dynamic. Efforts to repair or replace cartilage, tendon, muscle, and vasculature using materials that facilitate repair and regeneration have been ongoing for decades. However, materials that possess the mechanical, chemical, and resorption characteristics necessary to recapitulate these tissues have been difficult to mimic using synthetic resorbable biomaterials. Herein, we report a series of resorbable elastomer-like materials that are compositionally identical and possess varying ratios of cis:trans double bonds in the backbone. These features afford concomitant control over the mechanical and surface eroding degradation properties of these materials. We show the materials can be functionalized post-polymerization with bioactive species and enhance cell adhesion. Furthermore, an in vivo rat model demonstrates that degradation and resorption are dependent on succinate stoichiometry in the elastomers and the results show limited inflammation highlighting their potential for use in soft tissue regeneration and drug delivery.
巻・号 12(1)
ページ 446
公開日 2021-1-19
DOI 10.1038/s41467-020-20610-5
PII 10.1038/s41467-020-20610-5
PMID 33469013
PMC PMC7815890
MeSH 3T3 Cells Absorbable Implants* Animals Biocompatible Materials / chemistry* Cell Line Elastomers Female Humans Materials Testing Mesenchymal Stem Cells Mice Polymerization Rats Stereoisomerism Surface Properties Tensile Strength Tissue Engineering / methods* Tissue Scaffolds / chemistry*
IF 12.121
リソース情報
ヒト・動物細胞 MC3T3-E1(RCB1126)