RRC ID 69946
著者 Lee JW, Ong TG, Samian MR, Teh AH, Watanabe N, Osada H, Ong EBB.
タイトル Screening of selected ageing-related proteins that extend chronological life span in yeast Saccharomyces cerevisiae.
ジャーナル Sci Rep
Abstract Ageing-related proteins play various roles such as regulating cellular ageing, countering oxidative stress, and modulating signal transduction pathways amongst many others. Hundreds of ageing-related proteins have been identified, however the functions of most of these ageing-related proteins are not known. Here, we report the identification of proteins that extended yeast chronological life span (CLS) from a screen of ageing-related proteins. Three of the CLS-extending proteins, Ptc4, Zwf1, and Sme1, contributed to an overall higher survival percentage and shorter doubling time of yeast growth compared to the control. The CLS-extending proteins contributed to thermal and oxidative stress responses differently, suggesting different mechanisms of actions. The overexpression of Ptc4 or Zwf1 also promoted rapid cell proliferation during yeast growth, suggesting their involvement in cell division or growth pathways.
巻・号 11(1)
ページ 24148
公開日 2021-12-17
DOI 10.1038/s41598-021-03490-7
PII 10.1038/s41598-021-03490-7
PMID 34921163
PMC PMC8683414
MeSH Cell Proliferation* Humans Protein Phosphatase 2C / genetics Protein Phosphatase 2C / metabolism* Ribonucleoproteins, Small Nuclear / genetics Ribonucleoproteins, Small Nuclear / metabolism* Saccharomyces cerevisiae / genetics Saccharomyces cerevisiae / metabolism* Saccharomyces cerevisiae Proteins / genetics Saccharomyces cerevisiae Proteins / metabolism* Signal Transduction*
IF 3.998
リソース情報
酵母 S288C, MLC30M, BY4741