RRC ID 69955
Author Fu X, Teboul E, Weiss GL, Antonoudiou P, Borkar CD, Fadok JP, Maguire J, Tasker JG.
Title Gq neuromodulation of BLA parvalbumin interneurons induces burst firing and mediates fear-associated network and behavioral state transition in mice.
Journal Nat Commun
Abstract Patterned coordination of network activity in the basolateral amygdala (BLA) is important for fear expression. Neuromodulatory systems play an essential role in regulating changes between behavioral states, however the mechanisms underlying this neuromodulatory control of transitions between brain and behavioral states remain largely unknown. We show that chemogenetic Gq activation and α1 adrenoreceptor activation in mouse BLA parvalbumin (PV) interneurons induces a previously undescribed, stereotyped phasic bursting in PV neurons and time-locked synchronized bursts of inhibitory postsynaptic currents and phasic firing in BLA principal neurons. This Gq-coupled receptor activation in PV neurons suppresses gamma oscillations in vivo and in an ex vivo slice model, and facilitates fear memory recall, which is consistent with BLA gamma suppression during conditioned fear expression. Thus, here we identify a neuromodulatory mechanism in PV inhibitory interneurons of the BLA which regulates BLA network oscillations and fear memory recall.
Volume 13(1)
Pages 1290
Published 2022-3-11
DOI 10.1038/s41467-022-28928-y
PII 10.1038/s41467-022-28928-y
PMID 35277502
PMC PMC8917207
MeSH Animals Basolateral Nuclear Complex* / metabolism Fear Inhibitory Postsynaptic Potentials / physiology Interneurons / metabolism Mice Parvalbumins* / metabolism
IF 12.121
Mice RBRC03674