論文 - 詳細
| RRC ID | 6996 |
|---|---|
| 著者 | Sato T, Takagi R, Orito Y, Ono E, Hoshino T. |
| タイトル | Novel compounds of octahydroheptaprenyl mycolic acyl ester and monocyclic C35-terpene, heptaprenylcycline B, from non-pathogenic mycobacterium species. |
| ジャーナル | Biosci Biotechnol Biochem |
| Abstract |
A search for C(35)-terpenes from non-saponified extracts of 12 non-pathogenic Mycobacterium species was carried out. Octahydroheptaprenyl mycolic acyl esters were isolated from M. chlorophenolicum cells which were also found from M. thermoresistibile, M. vanbaalenii, M. aichiense, M. smegmatis, and M. parafortuitum. This is the first report on a polyprenol esterified by a mycolate. A novel monocyclic C(35)-terpene possessing a ketone, named heptaprenylcycline B, was isolated, which was detected from M. chlorophenolicum and M. vanbaalenii. The biosynthetic pathway to heptaprenylcycline B was investigated with ancymidol which acts as an inhibitor of a P450 monooxygenase. This experiment suggested that the P450 monooxygenase may be responsible for the production of heptaprenylcycline B. |
| 巻・号 | 74(1) |
| ページ | 147-51 |
| 公開日 | 2010-1-1 |
| DOI | 10.1271/bbb.90669 |
| PII | JST.JSTAGE/bbb/90669 |
| PMID | 20057120 |
| MeSH | Biocatalysis Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System / metabolism Enzyme Inhibitors / pharmacology Esters / chemistry* Esters / isolation & purification* Magnetic Resonance Spectroscopy Mass Spectrometry Mycobacterium / chemistry* Mycobacterium / metabolism Mycolic Acids / chemistry* Terpenes / chemistry Terpenes / isolation & purification* Terpenes / metabolism |
| IF | 1.516 |
| 引用数 | 10 |
| WOS 分野 | FOOD SCIENCE & TECHNOLOGY CHEMISTRY, APPLIED BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM 6377 JCM 6376 JCM 6366 JCM 7439 JCM 6371 JCM 6375 JCM 6364 JCM 6367 JCM 6370 JCM 6386 JCM 6362 JCM 13017 |