論文 - 詳細
RRC ID | 6998 |
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著者 | Ogura K, Sugahara T, Maruyama M, Akiyama K, Yamauchi S. |
タイトル | Improved syntheses of morinol C and D by employing Mizoroki-Heck reaction and their cytotoxic and antimicrobial activities. |
ジャーナル | Biosci Biotechnol Biochem |
Abstract |
Improved syntheses of optically pure (-)- and (+)-morinol C, and (-)- and (+)-morinol D were achieved by employing the Mizoroki-Heck reaction to construct the cinnamyl moiety. The protective group of the alkene substrate affected the yield of this key reaction. The reaction with a combination of the acetate-protected olefin and 4-methoxyphenylboronic acid gave the best result producing morinol C and D. All stereoisomers of morinol C and D showed cytotoxic activity, with (R,R)-morinol C showing the highest antibacterial activity. |
巻・号 | 74(8) |
ページ | 1641-4 |
公開日 | 2010-1-1 |
DOI | 10.1271/bbb.100255 |
PII | JST.JSTAGE/bbb/100255 |
PMID | 20699576 |
MeSH | Anti-Infective Agents / chemical synthesis* Anti-Infective Agents / chemistry Anti-Infective Agents / pharmacology* Anti-Infective Agents / toxicity Bacteria / drug effects Cell Line, Tumor Humans Microbial Sensitivity Tests Pyrans / chemical synthesis* Pyrans / chemistry Pyrans / pharmacology* Pyrans / toxicity |
IF | 1.516 |
引用数 | 3 |
WOS 分野 | FOOD SCIENCE & TECHNOLOGY CHEMISTRY, APPLIED BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY |
リソース情報 | |
一般微生物 | JCM 1649 JCM 11481 JCM 6977 JCM 7579 |