Reference - Detail
| RRC ID | 6999 |
|---|---|
| Author | Kondo S, Xiao JZ, Satoh T, Odamaki T, Takahashi S, Sugahara H, Yaeshima T, Iwatsuki K, Kamei A, Abe K. |
| Title | Antiobesity effects of Bifidobacterium breve strain B-3 supplementation in a mouse model with high-fat diet-induced obesity. |
| Journal | Biosci Biotechnol Biochem |
| Abstract |
The aim of the present study was to evaluate the anti-obesity activity of a probiotic bifidobacterial strain in a mouse model with obesity induced by a high-fat diet. The mice were fed a high-fat diet supplemented with Bifidobacterium breve B-3 at 10(8) or 10(9) CFU/d for 8 weeks. B. breve B-3 supplementation dose-dependently suppressed the accumulation of body weight and epididymal fat, and improved the serum levels of total cholesterol, fasting glucose and insulin. The bifidobacterial counts in the caecal contents and feces were significantly increased with the B. breve B-3 administration. The expression of genes related to fat metabolism and insulin sensitivity in the gut and epididymal fat tissue was up-regulated by this administration. These results suggest that the use of B. breve B-3 would be effective in reducing the risk of obesity. |
| Volume | 74(8) |
| Pages | 1656-61 |
| Published | 2010-1-1 |
| DOI | 10.1271/bbb.100267 |
| PII | JST.JSTAGE/bbb/100267 |
| PMID | 20699581 |
| MeSH | Adipose Tissue / metabolism Adipose Tissue / microbiology Administration, Oral Animals Bifidobacterium / physiology* Cecum / microbiology Dietary Fats / adverse effects* Disease Models, Animal Epididymis / microbiology Feces / microbiology Gene Expression Regulation / drug effects Insulin Resistance Intestinal Mucosa / metabolism Intestines / microbiology Lipid Metabolism / genetics Male Metagenome Mice Mice, Inbred C57BL Obesity / etiology* Obesity / immunology Obesity / metabolism Obesity / microbiology* Probiotics / administration & dosage Probiotics / pharmacology* RNA, Messenger / genetics RNA, Messenger / metabolism Serologic Tests |
| IF | 1.516 |
| Times Cited | 115 |
| WOS Category | FOOD SCIENCE & TECHNOLOGY CHEMISTRY, APPLIED BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Altmetric score |
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 31 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| General Microbes | JCM 11019 JCM 1131 |