| RRC ID |
70008
|
| 著者 |
Nagatomo A, Inoue N, Konno T, Xu Y, Sakamoto C, Sone M, Shibasaka A, Muraoka O, Ninomiya K, Yoshikawa M, Manse Y, Morikawa T.
|
| タイトル |
Ursane-type triterpene oligoglycosides with anti-hepatosteatosis and anti-hyperlipidemic activity from the leaves of Ilex paraguariensis A. St.-Hil.
|
| ジャーナル |
J Nat Med
|
| Abstract |
The methanol extract from the leaves of Ilex paraguariensis A. St.-Hil. (Aquifoliaceae), popularly known as mate, maté, or yerba maté, inhibits the intracellular triglyceride accumulation in HepG2 cells and suppresses the plasma triglyceride elevation in olive oil-treated mice. Three new triterpene saponins, termed mateosides I (1), II (2), and III (3), were isolated from the extract along with 29 known compounds. The structures of 1-3 were elucidated based on chemical and spectroscopic evidence. Among the isolates, principal saponin constituents, 2 and matesaponins 1 (7) and 2 (9), potently inhibited the triglyceride accumulation in HepG2 cells simultaneously treated with oleic acid and high glucose. In vivo assay of the methanol extract of I. paraguariensis revealed that 7 and 9 showed anti-hyperlipidemic activities in olive oil-treated mice. These results suggested that the saponin constituents of I. paraguariensis could be valuable bioactive marker for the anti-obesogenic activity.
|
| 巻・号 |
76(3)
|
| ページ |
654-669
|
| 公開日 |
2022-6-1
|
| DOI |
10.1007/s11418-022-01614-5
|
| PII |
10.1007/s11418-022-01614-5
|
| PMID |
35292883
|
| MeSH |
Animals
Ilex paraguariensis* / chemistry
Methanol
Mice
Olive Oil / analysis
Plant Extracts / analysis
Plant Extracts / pharmacology
Plant Extracts / therapeutic use
Plant Leaves / chemistry
Saponins* / analysis
Saponins* / pharmacology
Saponins* / therapeutic use
Triglycerides
Triterpenes* / analysis
Triterpenes* / pharmacology
Triterpenes* / therapeutic use
|
| IF |
2.055
|
| リソース情報 |
| ヒト・動物細胞 |
Hep G2(RCB1648) |
