| RRC ID |
7001
|
| Author |
Watanabe J, Fujiwara R, Sasajima N, Ito S, Sonoyama K.
|
| Title |
Administration of antibiotics during infancy promoted the development of atopic dermatitis-like skin lesions in NC/Nga mice.
|
| Journal |
Biosci Biotechnol Biochem
|
| Abstract |
This study aimed to determine whether oral antibiotic administration during infancy is associated with the spontaneous development of atopic dermatitis-like skin lesions by modulating intestinal microbiota. Female NC/Nga mice at 3 weeks of age were orally administered kanamycin or polymyxin B. Clinical symptoms, scratching behavior, and serum antibody levels were evaluated. Changes in intestinal microbiota were determined by culture-independent analysis and cultural analysis. The kanamycin-treated mice showed higher clinical scores and scratching frequency than the control mice. IgE levels were significantly higher in the kanamycin-treated mice than in the control mice. Transient changes in intestinal microbiota were observed under kanamycin treatment. Polymyxin B treatment failed to affect scratching behavior. These results suggest that oral administration of kanamycin during infancy promoted the development of atopic dermatitis-like skin lesions in NC/Nga mice and was associated with a transient change in intestinal microbiota.
|
| Volume |
74(2)
|
| Pages |
358-63
|
| Published |
2010-1-1
|
| DOI |
10.1271/bbb.90709
|
| PII |
JST.JSTAGE/bbb/90709
|
| PMID |
20139606
|
| MeSH |
Administration, Oral
Animals
Anti-Bacterial Agents / administration & dosage
Anti-Bacterial Agents / adverse effects*
Dermatitis, Atopic / pathology*
Female
Immunoglobulin E / blood
Mice
Mice, Inbred Strains
Pruritus / pathology
Severity of Illness Index
Skin / pathology*
|
| IF |
1.516
|
| Times Cited |
15
|
|
WOS Category
|
FOOD SCIENCE & TECHNOLOGY
CHEMISTRY, APPLIED
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| General Microbes |
JCM 1717 |
