論文 - 詳細
| RRC ID | 70025 |
|---|---|
| 著者 | Do KM, Shin MK, Kodama T, Win NN, Prema P, Nguyen HM, Hayakawa Y, Morita H. |
| タイトル | Flavanols and Flavanes from Crinum asiaticum and Their Effects on LPS Signaling Pathway Through the Inhibition of NF-κB Activation. |
| ジャーナル | Planta Med |
| Abstract |
Three new flavanols, (2R,3S)-7-methoxy-flavan-3-ol (1: ), (2R,3S)-7-hydroxy-flavan-3-ol (2: ), and (2R,3S)-2'-hydroxy-7-methoxy-flavan-3-ol (3: ), together with two known flavans (4: and 5: ), were isolated from the chloroform extract of Crinum asiaticum. Their structures were elucidated by various spectroscopic methods, including 1D and 2D NMR, HR-ESI-MS, and CD data. The isolated compounds 1: and 3: -5: showed inhibitory activity toward LPS-induced nitric oxide (NO) production. Further investigation of the NF-κB pathway mechanisms indicated that 1: and 3: -5: inhibited the LPS-induced IL-6 production and p65 subunit phosphorylation of NF-κB in RAW264.7 cells, with an effective dose of 10 µM. |
| 巻・号 | 88(11) |
| ページ | 913-920 |
| 公開日 | 2022-9-1 |
| DOI | 10.1055/a-1585-5877 |
| PMID | 34474490 |
| MeSH | Animals Crinum* / metabolism Flavonoids / chemistry* Lipopolysaccharides / pharmacology Mice NF-kappa B* / metabolism Nitric Oxide / metabolism Nitric Oxide Synthase Type II / metabolism Polyphenols RAW 264.7 Cells Signal Transduction |
| IF | 2.687 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | RAW 264(RCB0535) |