| RRC ID |
70117
|
| Author |
Castillo JA, Borchmann DE, Cheng AY, Wang Y, Hu C, García AJ, Weck M.
|
| Title |
Well-defined Poly(lactic acid)s Containing Poly(ethylene glycol) Side-chains.
|
| Journal |
Macromolecules
|
| Abstract |
Poly(ethylene glycol) (PEG) side-chain functionalized lactide analogues have been synthesized in four steps from commercially available L-lactide. The key step in the synthesis is the 1,3-dipolar cycloaddition between PEG-azides and a highly strained spirolactide-heptene monomer, which proceeds in high conversions. The PEG-grafted lactides analogues were polymerized via ring-opening polymerization using triazacyclodecene as organocatalyst to give well-defined tri- and hepta-(ethylene glycol)-poly(lactide)s (PLA) with molecular weights above 10 kDa and polydispersity indices between 1.6 and 2.1. PEG-poly(lactide) (PLA) with PEG chain M(n) 2000 was also prepared but GPC analysis showed a bimodal profile indicating the presence of starting macromonomer. Cell adhesion assays were performed using MC3T3 E-1 osteoblast-like cells demonstrating that PEG-containing PLA reduces cell adhesion significantly when compared to unfunctionalized PLA.
|
| Volume |
45(1)
|
| Pages |
62-69
|
| Published |
2012-1-1
|
| DOI |
10.1021/ma2016387
|
| PMID |
22279245
|
| PMC |
PMC3263433
|
| Resource |
| Human and Animal Cells |
MC3T3-E1(RCB1126) |
