| RRC ID |
70183
|
| 著者 |
Krasovec G, Hozumi A, Yoshida T, Obita T, Hamada M, Shiraishi A, Satake H, Horie T, Mori H, Sasakura Y.
|
| タイトル |
d-Serine controls epidermal vesicle release via NMDA receptor, allowing tissue migration during the metamorphosis of the chordate Ciona.
|
| ジャーナル |
Sci Adv
|
| Abstract |
d-Serine, a free amino acid synthesized by serine racemase, is a coagonist of N-methyl-d-aspartate-type glutamate receptor (NMDAR). d-Serine in the mammalian central nervous system modulates glutamatergic transmission. Functions of d-serine in mammalian peripheral tissues such as skin have also been described. However, d-serine's functions in nonmammals are unclear. Here, we characterized d-serine-dependent vesicle release from the epidermis during metamorphosis of the tunicate Ciona. d-Serine leads to the formation of a pocket that facilitates the arrival of migrating tissue during tail regression. NMDAR is the receptor of d-serine in the formation of the epidermal pocket. The epidermal pocket is formed by the release of epidermal vesicles' content mediated by d-serine/NMDAR. This mechanism is similar to observations of keratinocyte vesicle exocytosis in mammalian skin. Our findings provide a better understanding of the maintenance of epidermal homeostasis in animals and contribute to further evolutionary perspectives of d-amino acid function among metazoans.
|
| 巻・号 |
8(10)
|
| ページ |
eabn3264
|
| 公開日 |
2022-3-11
|
| DOI |
10.1126/sciadv.abn3264
|
| PMID |
35275721
|
| PMC |
PMC8916719
|
| MeSH |
Animals
Ciona* / metabolism
Ciona intestinalis* / metabolism
Epidermis / metabolism
Mammals / metabolism
Receptors, N-Methyl-D-Aspartate / metabolism
Serine / metabolism
|
| IF |
13.117
|
| リソース情報 |
| カタユウレイボヤ・(ニッポンウミシダ) |
Wild C. int |
