論文 - 詳細
RRC ID | 70228 |
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著者 | Bae M, An JS, Hong SH, Bae ES, Chung B, Kwon Y, Hong S, Oh KB, Shin J, Lee SK, Oh DC. |
タイトル | Donghaecyclinones A-C: New Cytotoxic Rearranged Angucyclinones from a Volcanic Island-Derived Marine Streptomyces sp. |
ジャーナル | Mar Drugs |
Abstract |
Chemical profiling of the Streptomyces sp. strain SUD119, which was isolated from a marine sediment sample collected from a volcanic island in Korea, led to the discovery of three new metabolites: donghaecyclinones A-C (1-3). The structures of 1-3 were found to be rearranged, multicyclic, angucyclinone-class compounds according to nuclear magnetic resonance (NMR) and mass spectrometry (MS) analyses. The configurations of their stereogenic centers were successfully assigned using a combination of quantum mechanics-based computational methods for calculating the NMR shielding tensor (DP4 and CP3) as well as electronic circular dichroism (ECD) along with a modified version of Mosher's method. Donghaecyclinones A-C (1-3) displayed cytotoxicity against diverse human cancer cell lines (IC50: 6.7-9.6 μM for 3). |
巻・号 | 18(2) |
公開日 | 2020-2-18 |
DOI | 10.3390/md18020121 |
PII | md18020121 |
PMID | 32085561 |
PMC | PMC7073551 |
MeSH | Anthraquinones / chemistry* Anthraquinones / isolation & purification Anthraquinones / pharmacology* Anti-Bacterial Agents Antifungal Agents Antineoplastic Agents Circular Dichroism Geologic Sediments / microbiology* Humans Islands Molecular Structure Republic of Korea Streptomyces / chemistry* |
IF | 4.073 |
リソース情報 | |
病原真核微生物 | Trichophyton mentagrophytes IFM 40996 |