論文 - 詳細
| RRC ID | 70359 |
|---|---|
| 著者 | Zhao H, Shi L, Li Z, Kong R, Ren X, Ma R, Jia L, Ma M, Lu S, Xu R, Binari R, Wang JH, Dong MQ, Perrimon N, Li Z. |
| タイトル | The Yun/Prohibitin complex regulates adult Drosophila intestinal stem cell proliferation through the transcription factor E2F1. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
Stem cells constantly divide and differentiate to maintain adult tissue homeostasis, and uncontrolled stem cell proliferation leads to severe diseases such as cancer. How stem cell proliferation is precisely controlled remains poorly understood. Here, from an RNA interference (RNAi) screen in adult Drosophila intestinal stem cells (ISCs), we identify a factor, Yun, required for proliferation of normal and transformed ISCs. Yun is mainly expressed in progenitors; our genetic and biochemical evidence suggest that it acts as a scaffold to stabilize the Prohibitin (PHB) complex previously implicated in various cellular and developmental processes and diseases. We demonstrate that the Yun/PHB complex is regulated by and acts downstream of EGFR/MAPK signaling. Importantly, the Yun/PHB complex interacts with and positively affects the levels of the transcription factor E2F1 to regulate ISC proliferation. In addition, we find that the role of the PHB complex in cell proliferation is evolutionarily conserved. Thus, our study uncovers a Yun/PHB-E2F1 regulatory axis in stem cell proliferation. |
| 巻・号 | 119(6) |
| 公開日 | 2022-2-8 |
| DOI | 10.1073/pnas.2111711119 |
| PII | 2111711119 |
| PMID | 35115400 |
| PMC | PMC8832997 |
| MeSH | Adult Stem Cells / metabolism* Animals Animals, Genetically Modified Cell Differentiation / physiology Cell Proliferation / physiology* Drosophila Proteins / metabolism* Drosophila melanogaster / metabolism* E2F1 Transcription Factor / metabolism* Homeostasis / physiology Intestines / metabolism* Prohibitins / metabolism* RNA Interference / physiology Signal Transduction / physiology |
| IF | 9.412 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 7705R-3 |