| RRC ID |
70367
|
| 著者 |
Zhao Y, Peng D, Liu Y, Zhang Q, Liu B, Deng Y, Ding W, Zhou Z, Liu Q.
|
| タイトル |
Usp8 promotes tumor cell migration through activating the JNK pathway.
|
| ジャーナル |
Cell Death Dis
|
| Abstract |
Tumor metastasis is the most cause of high mortality for cancer patients. Identification of novel factors that modulate tumor cell migration is of great significance for therapeutic strategies. Here, we find that the ubiquitin-specific protease 8 (Usp8) promotes tumor cell migration through activating the c-Jun N-terminal kinase (JNK) pathway. Genetic epistasis analyses uncover Usp8 acts upstream of Tak1 to control the JNK pathway. Consistently, biochemical results reveal that Usp8 binds Tak1 to remove ubiquitin modification from Tak1, leading to its stabilization. In addition, human USP8 also triggers tumor cell migration and activates the JNK pathway. Finally, we show that knockdown of USP8 in human breast cancer cells suppresses cell migration. Taken together, our findings demonstrate that a conserved Usp8-Tak1-JNK axis promotes tumor cell migration, and providing USP8 as a potential therapeutic target for cancer treatment.
|
| 巻・号 |
13(3)
|
| ページ |
286
|
| 公開日 |
2022-3-31
|
| DOI |
10.1038/s41419-022-04749-1
|
| PII |
10.1038/s41419-022-04749-1
|
| PMID |
35361778
|
| PMC |
PMC8971431
|
| MeSH |
Cell Movement
Endopeptidases / genetics
Endopeptidases / metabolism
Endosomal Sorting Complexes Required for Transport / metabolism
Humans
JNK Mitogen-Activated Protein Kinases / metabolism
MAP Kinase Signaling System*
Neoplasms* / genetics
Ubiquitin / metabolism
Ubiquitin Thiolesterase / genetics
Ubiquitin Thiolesterase / metabolism
|
| IF |
6.304
|
| リソース情報 |
| ショウジョウバエ |
5798R-1
DGRC#109029 |
