論文 - 詳細
| RRC ID | 70406 |
|---|---|
| 著者 | Hayashi MK, Sato K, Sekino Y. |
| タイトル | Neurons Induce Tiled Astrocytes with Branches That Avoid Each Other. |
| ジャーナル | Int J Mol Sci |
| Abstract |
Neurons induce astrocyte branches that approach synapses. Each astrocyte tiles by expanding branches in an exclusive territory, with limited entries for the neighboring astrocyte branches. However, how astrocytes form exclusive territories is not known. For example, the extensive branching of astrocytes may sterically interfere with the penetration of other astrocyte branches. Alternatively, astrocyte branches may actively avoid each other or remove overlapped branches to establish a territory. Here, we show time-lapse imaging of the multi-order branching process of GFP-labeled astrocytes. Astrocyte branches grow in the direction where other astrocyte branches do not exist. Neurons that had just started to grow dendrites were able to induce astrocyte branching and tiling. Upon neuronal loss by glutamate excitotoxicity, astrocytes' terminal processes retracted and more branches went over other branches. Our results indicate that neurons induce astrocyte branches and make them avoid each other. |
| 巻・号 | 23(8) |
| 公開日 | 2022-4-9 |
| DOI | 10.3390/ijms23084161 |
| PII | ijms23084161 |
| PMID | 35456979 |
| PMC | PMC9028504 |
| MeSH | Astrocytes* / physiology Glutamic Acid Neurons* / physiology Synapses / physiology |
| IF | 4.556 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 8 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | AQP4(E5415A-1H6-68)(RCB4883) |