| RRC ID |
70417
|
| Author |
Hwang W, Toda T, Yukawa M.
|
| Title |
Complementation of fission yeast kinesin-5/Cut7 with human Eg5 provides a versatile platform for screening of anticancer compounds.
|
| Journal |
Biosci Biotechnol Biochem
|
| Abstract |
Kinesin-5 family proteins are essential for bipolar spindle assembly to ensure mitotic fidelity. Here, we demonstrate evolutionary functional conservation of kinesin-5 between human and fission yeast. Human Eg5 expressed in the nucleus replaces fission yeast counterpart Cut7. Intriguingly, Eg5 overproduction results in cytotoxicity. This phenotype provides a useful platform for the development of novel kinesin-5 inhibitors as anticancer drugs.
|
| Volume |
86(2)
|
| Pages |
254-259
|
| Published |
2022-1-24
|
| DOI |
10.1093/bbb/zbab212
|
| PII |
6449361
|
| PMID |
34864879
|
| MeSH |
Schizosaccharomyces*
|
| IF |
1.516
|
| Resource |
| Yeast |
|
