Reference - Detail
| RRC ID | 70417 |
|---|---|
| Author | Hwang W, Toda T, Yukawa M. |
| Title | Complementation of fission yeast kinesin-5/Cut7 with human Eg5 provides a versatile platform for screening of anticancer compounds. |
| Journal | Biosci Biotechnol Biochem |
| Abstract |
Kinesin-5 family proteins are essential for bipolar spindle assembly to ensure mitotic fidelity. Here, we demonstrate evolutionary functional conservation of kinesin-5 between human and fission yeast. Human Eg5 expressed in the nucleus replaces fission yeast counterpart Cut7. Intriguingly, Eg5 overproduction results in cytotoxicity. This phenotype provides a useful platform for the development of novel kinesin-5 inhibitors as anticancer drugs. |
| Volume | 86(2) |
| Pages | 254-259 |
| Published | 2022-1-24 |
| DOI | 10.1093/bbb/zbab212 |
| PII | 6449361 |
| PMID | 34864879 |
| MeSH | Schizosaccharomyces* |
| IF | 1.516 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Yeast | |