| RRC ID |
70444
|
| 著者 |
Bartoszek EM, Ostenrath AM, Jetti SK, Serneels B, Mutlu AK, Chau KTP, Yaksi E.
|
| タイトル |
Ongoing habenular activity is driven by forebrain networks and modulated by olfactory stimuli.
|
| ジャーナル |
Curr Biol
|
| Abstract |
Ongoing neural activity, which represents internal brain states, is constantly modulated by the sensory information that is generated by the environment. In this study, we show that the habenular circuits act as a major brain hub integrating the structured ongoing activity of the limbic forebrain circuitry and the olfactory information. We demonstrate that ancestral homologs of amygdala and hippocampus in zebrafish forebrain are the major drivers of ongoing habenular activity. We also reveal that odor stimuli can modulate the activity of specific habenular neurons that are driven by this forebrain circuitry. Our results highlight a major role for the olfactory system in regulating the ongoing activity of the habenula and the forebrain, thereby altering brain's internal states.
|
| 巻・号 |
31(17)
|
| ページ |
3861-3874.e3
|
| 公開日 |
2021-9-13
|
| DOI |
10.1016/j.cub.2021.08.021
|
| PII |
S0960-9822(21)01125-8
|
| PMID |
34416179
|
| PMC |
PMC8445323
|
| MeSH |
Animals
Habenula* / physiology
Nervous System
Neurons
Smell
Zebrafish / physiology
|
| IF |
9.601
|
| リソース情報 |
| ゼブラフィッシュ |
Tg(dao:GAL4VP16)rw0148a
Tg(narp:GAL4VP16)rw0143a
Tg(UAS:nfsB-mCherry)rw0144 |
