Reference - Detail
| RRC ID | 70447 |
|---|---|
| Author | Zhao S, Feng S, Tian Y, Wen Z. |
| Title | Hemogenic and aortic endothelium arise from a common hemogenic angioblast precursor and are specified by the Etv2 dosage. |
| Journal | Proc Natl Acad Sci U S A |
| Abstract |
SignificanceHematopoietic stem cells (HSCs) are generated from specialized endothelial cells, called hemogenic endothelial cells (HECs). It has been debated whether HECs and non-HSC-forming conventional endothelial cells (cECs) arise from a common precursor or represent distinct lineages. Moreover, the molecular basis underlying their distinct fate determination is poorly understood. We use photoconvertible labeling, time-lapse imaging, and single-cell RNA-sequencing analysis to trace the lineage of HECs. We discovered that HECs and cECs arise from a common hemogenic angioblast precursor, and their distinct fate is determined by high or low dosage of Etv2, respectively. Our results illuminate the lineage origin and a mechanism on the fate determination of HECs, which may enhance the understanding on the ontogeny of HECs in vertebrates. |
| Volume | 119(13) |
| Pages | e2119051119 |
| Published | 2022-3-29 |
| DOI | 10.1073/pnas.2119051119 |
| PMID | 35333649 |
| PMC | PMC9060440 |
| MeSH | Animals Cell Differentiation Endothelium, Vascular Hemangioblasts* Hematopoiesis* |
| IF | 9.412 |
| Altmetric score |
オルトメトリクス指標項目
|
| The most frequently cited source | X(Twitter) |
| Total number of mentions | 6 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Zebrafish | Tg(kdrl:NLS-Eos)ncv6Tg |