論文 - 詳細
| RRC ID | 70453 |
|---|---|
| 著者 | Jenkins BH, Maguire F, Leonard G, Eaton JD, West S, Housden BE, Milner DS, Richards TA. |
| タイトル | Emergent RNA-RNA interactions can promote stability in a facultative phototrophic endosymbiosis. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
Significance
Stable endosymbiosis between eukaryotic microbes has driven the evolution of further cellular complexity. Yet the mechanisms that can act to stabilize an emergent eukaryote–eukaryote endosymbiosis are unclear. Using the model facultative endosymbiotic system,
Paramecium bursaria
, we demonstrate that endosymbiont–host RNA–RNA interactions can drive a cost to host growth upon endosymbiont digestion. These RNA–RNA interactions are facilitated by the host RNA-interference system. For endosymbiont messenger RNA sharing a high level of sequence identity with host transcripts, this process can result in host gene knockdown. We propose that these endosymbiont–host RNA–RNA interactions—“RNA-interference collisions”—represent an emergent mechanism to sanction the host for breakdown of the endosymbiosis, promoting the stability of the facultative endosymbiotic interaction. |
| 巻・号 | 118(38) |
| 公開日 | 2021-9-21 |
| DOI | 10.1073/pnas.2108874118 |
| PII | 2108874118 |
| PMID | 34521754 |
| PMC | PMC8463893 |
| MeSH | Chlorella / genetics Chloroplasts / genetics Eukaryota / genetics Paramecium / genetics Phototrophic Processes / genetics* Plastids / genetics RNA / genetics* RNA Interference / physiology Symbiosis / genetics* |
| IF | 9.412 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 33 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゾウリムシ | Yad1g1N |