Reference - Detail
| RRC ID | 70515 |
|---|---|
| Author | Yasuda M, Habib AGK, Sugiura K, Shamim HM, Ueno M. |
| Title | The fission yeast bromodomain protein Bdf2 is required for the growth of cells with circular chromosomes. |
| Journal | Biosci Biotechnol Biochem |
| Abstract |
Circular chromosomes have frequently been observed in tumors of mesenchymal origin. In the fission yeast Schizosaccharomyces pombe, deletion of pot1+ results in rapid telomere loss, and the resulting survivors have circular chromosomes. Fission yeast has 2 bromodomain and extra-terminal (BET) proteins, Bdf1 and Bdf2; both are required for maintaining acetylated histones. Here, we found that bdf2, but not bdf1, was synthetically lethal with pot1. We also obtained a temperature-sensitive bdf2-ts mutant, which can grow at high temperatures but becomes camptothecin sensitive. This suggests that Bdf2 is defective at high temperatures. The cell cycle of the pot1 bdf2-ts mutant was delayed in the G2 and/or M phase at a semipermissive temperature. Furthermore, a temperature-sensitive mutant of mst1, which encodes histone acetyltransferase, showed a synthetic growth defect with a pot1 disruptant at a semipermissive temperature. Our results suggest that Bdf2 and Mst1 are required for the growth of cells with circular chromosomes. |
| Volume | 86(2) |
| Pages | 224-230 |
| Published | 2022-1-24 |
| DOI | 10.1093/bbb/zbab215 |
| PII | 6464124 |
| PMID | 34918022 |
| MeSH | Schizosaccharomyces* |
| IF | 1.516 |
| Altmetric score |
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Yeast | |