| RRC ID |
70548
|
| 著者 |
Rapacka-Zdonczyk A, Wozniak A, Kruszewska B, Waleron K, Grinholc M.
|
| タイトル |
Can Gram-Negative Bacteria Develop Resistance to Antimicrobial Blue Light Treatment?
|
| ジャーナル |
Int J Mol Sci
|
| Abstract |
Antimicrobial blue light (aBL) treatment is considered low risk for the development of bacterial resistance and tolerance due to its multitarget mode of action. The aim of the current study was to demonstrate whether tolerance development occurs in Gram-negative bacteria. We evaluated the potential of tolerance/resistance development in Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa and demonstrated that representative Gram-negative bacteria may develop tolerance to aBL. The observed adaption was a stable feature. Assays involving E. coli K-12 tolC-, tolA-, umuD-, and recA-deficient mutants revealed some possible mechanisms for aBL tolerance development.
|
| 巻・号 |
22(21)
|
| 公開日 |
2021-10-27
|
| DOI |
10.3390/ijms222111579
|
| PII |
ijms222111579
|
| PMID |
34769009
|
| PMC |
PMC8583887
|
| MeSH |
Anti-Bacterial Agents / therapeutic use
Drug Resistance, Bacterial / genetics*
Escherichia coli Proteins / genetics
Gram-Negative Bacteria / genetics*
Light
Phototherapy / methods
|
| IF |
4.556
|
| リソース情報 |
| 原核生物(大腸菌) |
Keio collection |
