論文 - 詳細
| RRC ID | 70552 |
|---|---|
| 著者 | Nordholt N, Kanaris O, Schmidt SBI, Schreiber F. |
| タイトル | Persistence against benzalkonium chloride promotes rapid evolution of tolerance during periodic disinfection. |
| ジャーナル | Nat Commun |
| Abstract |
Biocides used as disinfectants are important to prevent the transmission of pathogens, especially during the current antibiotic resistance crisis. This crisis is exacerbated by phenotypically tolerant persister subpopulations that can survive transient antibiotic treatment and facilitate resistance evolution. Here, we show that E. coli displays persistence against a widely used disinfectant, benzalkonium chloride (BAC). Periodic, persister-mediated failure of disinfection rapidly selects for BAC tolerance, which is associated with reduced cell surface charge and mutations in the lpxM locus, encoding an enzyme for lipid A biosynthesis. Moreover, the fitness cost incurred by BAC tolerance turns into a fitness benefit in the presence of antibiotics, suggesting a selective advantage of BAC-tolerant mutants in antibiotic environments. Our findings highlight the links between persistence to disinfectants and resistance evolution to antimicrobials. |
| 巻・号 | 12(1) |
| ページ | 6792 |
| 公開日 | 2021-11-23 |
| DOI | 10.1038/s41467-021-27019-8 |
| PII | 10.1038/s41467-021-27019-8 |
| PMID | 34815390 |
| PMC | PMC8611074 |
| MeSH | Acyltransferases Anti-Bacterial Agents / pharmacology* Anti-Bacterial Agents / therapeutic use Benzalkonium Compounds / pharmacology Disinfectants / pharmacology* Disinfection / methods Drug Resistance, Bacterial / genetics* Escherichia coli / drug effects* Escherichia coli / genetics Escherichia coli Proteins Evolution, Molecular* Genetic Loci Microbial Sensitivity Tests |
| IF | 12.121 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 12 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 原核生物(大腸菌) | JW1844-AM JW2557-AM JW1844-KC BW25113 |