論文 - 詳細
| RRC ID | 70582 |
|---|---|
| 著者 | Graca FA, Rai M, Hunt LC, Stephan A, Wang YD, Gordon B, Wang R, Quarato G, Xu B, Fan Y, Labelle M, Demontis F. |
| タイトル | The myokine Fibcd1 is an endogenous determinant of myofiber size and mitigates cancer-induced myofiber atrophy. |
| ジャーナル | Nat Commun |
| Abstract |
Decline in skeletal muscle cell size (myofiber atrophy) is a key feature of cancer-induced wasting (cachexia). In particular, atrophy of the diaphragm, the major muscle responsible for breathing, is an important determinant of cancer-associated mortality. However, therapeutic options are limited. Here, we have used Drosophila transgenic screening to identify muscle-secreted factors (myokines) that act as paracrine regulators of myofiber growth. Subsequent testing in mouse myotubes revealed that mouse Fibcd1 is an evolutionary-conserved myokine that preserves myofiber size via ERK signaling. Local administration of recombinant Fibcd1 (rFibcd1) ameliorates cachexia-induced myofiber atrophy in the diaphragm of mice bearing patient-derived melanoma xenografts and LLC carcinomas. Moreover, rFibcd1 impedes cachexia-associated transcriptional changes in the diaphragm. Fibcd1-induced signaling appears to be muscle selective because rFibcd1 increases ERK activity in myotubes but not in several cancer cell lines tested. We propose that rFibcd1 may help reinstate myofiber size in the diaphragm of patients with cancer cachexia. |
| 巻・号 | 13(1) |
| ページ | 2370 |
| 公開日 | 2022-5-2 |
| DOI | 10.1038/s41467-022-30120-1 |
| PII | 10.1038/s41467-022-30120-1 |
| PMID | 35501350 |
| PMC | PMC9061726 |
| MeSH | Animals Atrophy / metabolism Cachexia* / metabolism Humans Mice Muscle Fibers, Skeletal / metabolism Muscle, Skeletal / metabolism Neoplasms* / complications Neoplasms* / genetics Neoplasms* / metabolism Receptors, Cell Surface / metabolism |
| IF | 12.121 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 24 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 15537R-2 10593R-1 10593R-3 11062R-1 11062R-2 HMJ21762 9621R-1 9621R-3 HMJ23437 8827R-1 8827R-2 6378R-1 6378R-4 4608R-1 4608R-2 HMJ23358 10186R-1 10186R-4 13830R-1 13830R-3 15537R-1 8343R-1 8343R-2 8483R-1 8483R-3 8642R-1 8642R-2 9400R-2 9400R-4 9849R-1 9849R-2 1869R-1 17633R-2 16987R-1 17919R-2 16987R-2 9885R-1 17919R-3 9885R-2 15388R-3 15388R-4 1889R-3 HMJ21232 HMJ30018 HMJ23751 31999R-1 31999R-4 HMJ30197 HMJ30283 12956R-1 12956R-3 5562R-1 5562R-3 17610R-2 16933R-3 17610R-4 4475R-1 4475R-2 4559R-2 4559R-3 1780R-1 1780R-4 HMJ23141 HMS00476 7532R-1 7532R-3 3322R-2 3322R-3 6232R-1 6232R-2 1901R-3 7103R-1 1901R-4 HMJ22320 HMJ22563 7103R-2 4859R-1 HMC03278 4859R-5 HMJ23143 11064R-2 1794-1R-1 11064R-3 1794-1R-2 1838R-1 17579R-1 1838R-3 18657R-1 17579R-2 18657R-2 3837R-1 16933R-1 3837R-9 4700R-1 4700R-2 9027R-2 9027R-4 10334R-2 3074R-1 HMJ23126 6281R-1 6281R-2 6868R-2 6868R-3 HMJ23300 12497R-1 11326R-2 11326R-3 4889R-3 4889R-4 4698R-2 4698R-3 6407R-1 |