論文 - 詳細
| RRC ID | 70673 |
|---|---|
| 著者 | Wiggin TD, Montgomery JE, Brunick AJ, Peck JH, Masino MA. |
| タイトル | V3 Interneurons Are Active and Recruit Spinal Motor Neurons during In Vivo Fictive Swimming in Larval Zebrafish. |
| ジャーナル | eNeuro |
| Abstract |
Survival for vertebrate animals is dependent on the ability to successfully find food, locate a mate, and avoid predation. Each of these behaviors requires motor control, which is set by a combination of kinematic properties. For example, the frequency and amplitude of motor output combine in a multiplicative manner to determine features of locomotion such as distance traveled, speed, force (thrust), and vigor. Although there is a good understanding of how different populations of excitatory spinal interneurons establish locomotor frequency, there is a less thorough mechanistic understanding for how locomotor amplitude is established. Recent evidence indicates that locomotor amplitude is regulated in part by a subset of functionally and morphologically distinct V2a excitatory spinal interneurons (Type II, nonbursting) in larval and adult zebrafish. Here, we provide direct evidence that most V3 interneurons (V3-INs), which are a developmentally and genetically defined population of ventromedial glutamatergic spinal neurons, are active during fictive swimming. We also show that elimination of the spinal V3-IN population reduces the proportion of active motor neurons (MNs) during fictive swimming but does not alter the range of locomotor frequencies produced. These data are consistent with V3-INs providing excitatory drive to spinal MNs during swimming in larval zebrafish and may contribute to the production of locomotor amplitude independently of locomotor frequency. |
| 巻・号 | 9(2) |
| 公開日 | 2022-1-1 |
| DOI | 10.1523/ENEURO.0476-21.2022 |
| PII | ENEURO.0476-21.2022 |
| PMID | 35277451 |
| PMC | PMC8970435 |
| MeSH | Animals Interneurons / physiology Larva / physiology Locomotion / physiology Motor Neurons / physiology Spinal Cord / physiology Swimming* / physiology Zebrafish* |
| IF | 3.544 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | Tg(vglut2a:loxP-DsRed-loxP-GFP) Tg(vglut2a:Gal4) UAS:GCaMP6s |