RRC ID 70678
Author Pallucchi I, Bertuzzi M, Michel JC, Miller AC, El Manira A.
Title Transformation of an early-established motor circuit during maturation in zebrafish.
Journal Cell Rep
Abstract Locomotion is mediated by spinal circuits that generate movements with a precise coordination and vigor. The assembly of these circuits is defined early during development; however, whether their organization and function remain invariant throughout development is unclear. Here, we show that the first established fast circuit between two dorsally located V2a interneuron types and the four primary motoneurons undergoes major transformation in adult zebrafish compared with what was reported in larvae. There is a loss of existing connections and establishment of new connections combined with alterations in the mode, plasticity, and strength of synaptic transmission. In addition, we show that this circuit no longer serves as a swim rhythm generator, but instead its components become embedded within the spinal escape circuit and control propulsion following the initial escape turn. Our results thus reveal significant changes in the organization and function of a motor circuit as animals develop toward adulthood.
Volume 39(2)
Pages 110654
Published 2022-4-12
DOI 10.1016/j.celrep.2022.110654
PII S2211-1247(22)00406-5
PMID 35417694
PMC PMC9071512
MeSH Animals Interneurons / physiology Locomotion / physiology Motor Neurons* / physiology Spinal Cord / physiology Zebrafish* / physiology
IF 8.109
Zebrafish Tg(chx10:GFP)nns1 Tg(chx10:loxp-dsRED-loxp-GFP)nns3 Tol-056 Tg(vglut2a:|R|-Gal4)