論文 - 詳細
| RRC ID | 70690 |
|---|---|
| 著者 | Hayashi Y, Kawabata KC, Tanaka Y, Uehara Y, Mabuchi Y, Murakami K, Nishiyama A, Kiryu S, Yoshioka Y, Ota Y, Sugiyama T, Mikami K, Tamura M, Fukushima T, Asada S, Takeda R, Kunisaki Y, Fukuyama T, Yokoyama K, Uchida T, Hagihara M, Ohno N, Usuki K, Tojo A, Katayama Y, Goyama S, Arai F, Tamura T, Nagasawa T, Ochiya T, Inoue D, Kitamura T. |
| タイトル | MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis. |
| ジャーナル | Cell Rep |
| Abstract |
Myelodysplastic syndrome (MDS) is a clonal disorder of hematopoietic stem cells (HSCs), characterized by ineffective hematopoiesis and frequent progression to leukemia. It has long remained unresolved how MDS cells, which are less proliferative, inhibit normal hematopoiesis and eventually dominate the bone marrow space. Despite several studies implicating mesenchymal stromal or stem cells (MSCs), a principal component of the HSC niche, in the inhibition of normal hematopoiesis, the molecular mechanisms underlying this process remain unclear. Here, we demonstrate that both human and mouse MDS cells perturb bone metabolism by suppressing the osteolineage differentiation of MSCs, which impairs the ability of MSCs to support normal HSCs. Enforced MSC differentiation rescues the suppressed normal hematopoiesis in both in vivo and in vitro MDS models. Intriguingly, the suppression effect is reversible and mediated by extracellular vesicles (EVs) derived from MDS cells. These findings shed light on the novel MDS EV-MSC axis in ineffective hematopoiesis. |
| 巻・号 | 39(6) |
| ページ | 110805 |
| 公開日 | 2022-5-10 |
| DOI | 10.1016/j.celrep.2022.110805 |
| PII | S2211-1247(22)00572-1 |
| PMID | 35545056 |
| MeSH | Animals Extracellular Vesicles* / metabolism Hematopoiesis Hematopoietic Stem Cells / metabolism Mesenchymal Stem Cells* / metabolism Mice Myelodysplastic Syndromes* / metabolism |
| IF | 8.109 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 50 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MSC-R37(HMS0020) 10T1/2(RCB0247) |