RRC ID 70712
Author Mast E, Bieser KL, Abraham-Villa M, Adams V, Akinlehin AJ, Aquino LZ, Austin JL, Austin AK, Beckham CN, Bengson EJ, Bieszk A, Bogard BL, Brennan RC, Brnot RM, Cirone NJ, Clark MR, Cooper BN, Cruz D, Daprizio KA, DeBoe J, Dencker MM, Donnelly LL, Driscoll L, DuBeau RJ, Durso SW, Ejub A, Elgosbi W, Estrada M, Evins K, Fox PD, France JM, Franco Hernandez MG, Garcia LA, Garl O, Gorsuch MR, Gorzeman-Mohr MA, Grothouse ME, Gubbels ME, Hakemiamjad R, Harvey CV, Hoeppner MA, Ivanov JL, Johnson VM, Johnson JL, Johnson A, Johnston K, Keller KR, Kennedy BT, Killian LR, Klumb M, Koehn OL, Koym AS, Kress KJ, Landis RE, Lewis KN, Lim E, Lopez IK, Lowe D, Luengo Carretero P, Lunaburg G, Mallinder SL, Marshall NA, Mathew J, Mathew J, Mcmanaway HS, Meegan EN, Meyst JD, Miller MJ, Minogue CK, Mohr AA, Moran CI, Moran A, Morris MD, Morrison MD, Moses EA, Mullins CJ, Neri CI, Nichols JM, Nickels BR, Okai AM, Okonmah C, Paramo M, Paramo M, Parker SL, Parmar NK, Paschal J, Patel P, Patel D, Perkins EB, Perry MM, Perry Z, Pollock AA, Portalatin O, Proffitt KS, Queen JT, Quemeneur AC, Richardson AG, Rosenberger K, Rutherford AM, Santos-Perez IX, Sarti CY, Schouweiler LJ, Sessing LM, Setaro SO, Silvestri CF, Smith OA, Smith MJ, Sumner JC, Sutton RR, Sweckard L, Talbott NB, Traxler PA, Truesdell J, Valenti AF, Verace L, Vijayakumar P, Wadley WL, Walter KE, Williams AR, Wilson TJ, Witbeck MA, Wobler TM, Wright LJ, Zuczkowska KA, Devergne O, Hamill DR, Shah HP, Siders J, Taylor EE, Vrailas-Mortimer AD, Kagey JD.
Title Genetic mapping of Uba3 O.2.2 , a pupal lethal mutation in Drosophila melanogaster.
Journal MicroPubl Biol
Abstract An EMS mutagenesis screen was conducted in Drosophila melanogaster to identify growth control mutants. The multi-institution Fly-CURE consortium phenotypically characterized the O.2.2 mutant using the FLP/FRT system which displayed a mutant lethal phenotype with reduced head development, and darkened ocular tissue. Complementation mapping was conducted to identify the affected gene. A failure to complement was identified in Uba3 , resulting in the identification of the novel allele, Uba3 O.2.2 . Uba3 is a known disruptor of the cell cycle and our data are consistent with early larval/embryonic lethality displayed in numerous species.
Volume 2022
Published 2022-1-1
DOI 10.17912/micropub.biology.000542
PMID 35622528
PMC PMC9012533
Resource
Drosophila DGRC#122114