論文 - 詳細
| RRC ID | 70716 |
|---|---|
| 著者 | Sênos Demarco R, Stack BJ, Tang AM, Voog J, Sandall SL, Southall TD, Brand AH, Jones DL. |
| タイトル | Escargot controls somatic stem cell maintenance through the attenuation of the insulin receptor pathway in Drosophila. |
| ジャーナル | Cell Rep |
| Abstract |
Adult stem cells coordinate intrinsic and extrinsic, local and systemic, cues to maintain the proper balance between self-renewal and differentiation. However, the precise mechanisms stem cells use to integrate these signals remain elusive. Here, we show that Escargot (Esg), a member of the Snail family of transcription factors, regulates the maintenance of somatic cyst stem cells (CySCs) in the Drosophila testis by attenuating the activity of the pro-differentiation insulin receptor (InR) pathway. Esg positively regulates the expression of an antagonist of insulin signaling, ImpL2, while also attenuating the expression of InR. Furthermore, Esg-mediated repression of the InR pathway is required to suppress CySC loss in response to starvation. Given the conservation of Snail-family transcription factors, characterizing the mechanisms by which Esg regulates cell-fate decisions during homeostasis and a decline in nutrient availability is likely to provide insight into the metabolic regulation of stem cell behavior in other tissues and organisms. |
| 巻・号 | 39(3) |
| ページ | 110679 |
| 公開日 | 2022-4-19 |
| DOI | 10.1016/j.celrep.2022.110679 |
| PII | S2211-1247(22)00431-4 |
| PMID | 35443165 |
| PMC | PMC9043617 |
| MeSH | Adult Stem Cells* / metabolism Animals Cell Differentiation Drosophila / metabolism Drosophila Proteins* / genetics Drosophila Proteins* / metabolism Drosophila melanogaster / metabolism Insulin-Like Growth Factor Binding Proteins / metabolism Male Receptor, Insulin / metabolism Testis Transcription Factors / genetics Transcription Factors / metabolism |
| IF | 8.109 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 23 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#117649 |