RRC ID 70716
著者 Sênos Demarco R, Stack BJ, Tang AM, Voog J, Sandall SL, Southall TD, Brand AH, Jones DL.
タイトル Escargot controls somatic stem cell maintenance through the attenuation of the insulin receptor pathway in Drosophila.
ジャーナル Cell Rep
Abstract Adult stem cells coordinate intrinsic and extrinsic, local and systemic, cues to maintain the proper balance between self-renewal and differentiation. However, the precise mechanisms stem cells use to integrate these signals remain elusive. Here, we show that Escargot (Esg), a member of the Snail family of transcription factors, regulates the maintenance of somatic cyst stem cells (CySCs) in the Drosophila testis by attenuating the activity of the pro-differentiation insulin receptor (InR) pathway. Esg positively regulates the expression of an antagonist of insulin signaling, ImpL2, while also attenuating the expression of InR. Furthermore, Esg-mediated repression of the InR pathway is required to suppress CySC loss in response to starvation. Given the conservation of Snail-family transcription factors, characterizing the mechanisms by which Esg regulates cell-fate decisions during homeostasis and a decline in nutrient availability is likely to provide insight into the metabolic regulation of stem cell behavior in other tissues and organisms.
巻・号 39(3)
ページ 110679
公開日 2022-4-19
DOI 10.1016/j.celrep.2022.110679
PII S2211-1247(22)00431-4
PMID 35443165
PMC PMC9043617
MeSH Adult Stem Cells* / metabolism Animals Cell Differentiation Drosophila / metabolism Drosophila Proteins* / genetics Drosophila Proteins* / metabolism Drosophila melanogaster / metabolism Insulin-Like Growth Factor Binding Proteins / metabolism Male Receptor, Insulin / metabolism Testis Transcription Factors / genetics Transcription Factors / metabolism
IF 8.109
リソース情報
ショウジョウバエ DGRC#117649