RRC ID 70717
Author Vrontou E, Groschner LN, Szydlowski S, Brain R, Krebbers A, Miesenböck G.
Title Response competition between neurons and antineurons in the mushroom body.
Journal Curr Biol
Abstract The mushroom bodies of Drosophila contain circuitry compatible with race models of perceptual choice. When flies discriminate odor intensity differences, opponent pools of αβ core Kenyon cells (on and off αβc KCs) accumulate evidence for increases or decreases in odor concentration. These sensory neurons and "antineurons" connect to a layer of mushroom body output neurons (MBONs) which bias behavioral intent in opposite ways. All-to-all connectivity between the competing integrators and their MBON partners allows for correct and erroneous decisions; dopaminergic reinforcement sets choice probabilities via reciprocal changes to the efficacies of on and off KC synapses; and pooled inhibition between αβc KCs can establish equivalence with the drift-diffusion formalism known to describe behavioral performance. The response competition network gives tangible form to many features envisioned in theoretical models of mammalian decision making, but it differs from these models in one respect: the principal variables-the fill levels of the integrators and the strength of inhibition between them-are represented by graded potentials rather than spikes. In pursuit of similar computational goals, a small brain may thus prioritize the large information capacity of analog signals over the robustness and temporal processing span of pulsatile codes.
Volume 31(22)
Pages 4911-4922.e4
Published 2021-11-22
DOI 10.1016/j.cub.2021.09.008
PII S0960-9822(21)01248-3
PMID 34610272
PMC PMC8612741
MeSH Animals Drosophila / physiology Drosophila melanogaster / physiology Mammals Mushroom Bodies* / physiology Neurons* / physiology Odorants Smell / physiology Synapses / physiology
IF 9.601
Drosophila DGRC#105080 DGRC#114120