Reference - Detail
| RRC ID | 70720 |
|---|---|
| Author | Wang R, Miao G, Shen JL, Fortier TM, Baehrecke EH. |
| Title | ESCRT dysfunction compromises endoplasmic reticulum maturation and autophagosome biogenesis in Drosophila. |
| Journal | Curr Biol |
| Abstract |
Autophagy targets cytoplasmic materials for degradation and influences cell health. Organelle contact and trafficking systems provide membranes for autophagosome formation, but how different membrane systems are selected for use during autophagy remains unclear. Here, we report a novel function of the endosomal sorting complex required for transport (ESCRT) in the regulation of endoplasmic reticulum (ER) coat protein complex II (COPII) vesicle formation that influences autophagy. The ESCRT functions in a pathway upstream of Vps13D to influence COPII vesicle transport, ER-Golgi intermediate compartment (ERGIC) assembly, and autophagosome formation. Atg9 functions downstream of the ESCRT to facilitate ERGIC and autophagosome formation. Interestingly, cells lacking either ESCRT or Vps13D functions exhibit dilated ER structures that are similar to cranio-lenticulo-sutural dysplasia patient cells with SEC23A mutations, which encodes a component of COPII vesicles. Our data reveal a novel ESCRT-dependent pathway that influences the ERGIC and autophagosome formation. |
| Volume | 32(6) |
| Pages | 1262-1274.e4 |
| Published | 2022-3-28 |
| DOI | 10.1016/j.cub.2022.01.040 |
| PII | S0960-9822(22)00093-8 |
| PMID | 35134326 |
| PMC | PMC8969116 |
| MeSH | Animals Autophagosomes* / metabolism Autophagy / physiology Autophagy-Related Proteins / genetics Autophagy-Related Proteins / metabolism Drosophila / metabolism Drosophila Proteins* / genetics Drosophila Proteins* / metabolism Endoplasmic Reticulum / metabolism Endosomal Sorting Complexes Required for Transport / genetics Endosomal Sorting Complexes Required for Transport / metabolism Golgi Apparatus / metabolism Humans Membrane Proteins / metabolism Protein Transport / physiology Proteins / metabolism |
| IF | 9.601 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 27 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | |