論文 - 詳細
| RRC ID | 70722 |
|---|---|
| 著者 | Georganta EM, Moressis A, Skoulakis EMC. |
| タイトル | Associative Learning Requires Neurofibromin to Modulate GABAergic Inputs to Drosophila Mushroom Bodies. |
| ジャーナル | J Neurosci |
| Abstract |
Cognitive dysfunction is among the hallmark symptoms of Neurofibromatosis 1, and accordingly, loss of the Drosophila melanogaster ortholog of Neurofibromin 1 (dNf1) precipitates associative learning deficits. However, the affected circuitry in the adult CNS remained unclear and the compromised mechanisms debatable. Although the main evolutionarily conserved function attributed to Nf1 is to inactivate Ras, decreased cAMP signaling on its loss has been thought to underlie impaired learning. Using mixed sex populations, we determine that dNf1 loss results in excess GABAergic signaling to the central for associative learning mushroom body (MB) neurons, apparently suppressing learning. dNf1 is necessary and sufficient for learning within these non-MB neurons, as a dAlk and Ras1-dependent, but PKA-independent modulator of GABAergic neurotransmission. Surprisingly, we also uncovered and discuss a postsynaptic Ras1-dependent, but dNf1-independnet signaling within the MBs that apparently responds to presynaptic GABA levels and contributes to the learning deficit of the mutants. |
| 巻・号 | 41(24) |
| ページ | 5274-5286 |
| 公開日 | 2021-6-16 |
| DOI | 10.1523/JNEUROSCI.1605-20.2021 |
| PII | JNEUROSCI.1605-20.2021 |
| PMID | 33972401 |
| PMC | PMC8211548 |
| MeSH | Animals Association Learning / physiology* Cyclic AMP / metabolism Drosophila Proteins / metabolism* Drosophila melanogaster Mushroom Bodies / metabolism* Nerve Tissue Proteins / metabolism* Signal Transduction / physiology gamma-Aminobutyric Acid / metabolism* ras GTPase-Activating Proteins / metabolism* ras Proteins / metabolism |
| IF | 5.674 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#104937 |