論文 - 詳細
| RRC ID | 70736 |
|---|---|
| 著者 | Lu J, Wang Y, Wang X, Wang D, Pflugfelder GO, Shen J. |
| タイトル | The Tbx6 Transcription Factor Dorsocross Mediates Dpp Signaling to Regulate Drosophila Thorax Closure. |
| ジャーナル | Int J Mol Sci |
| Abstract |
Movement and fusion of separate cell populations are critical for several developmental processes, such as neural tube closure in vertebrates or embryonic dorsal closure and pupal thorax closure in Drosophila. Fusion failure results in an opening or groove on the body surface. Drosophila pupal thorax closure is an established model to investigate the mechanism of tissue closure. Here, we report the identification of T-box transcription factor genes Dorsocross (Doc) as Decapentaplegic (Dpp) targets in the leading edge cells of the notum in the late third instar larval and early pupal stages. Reduction of Doc in the notum region results in a thorax closure defect, similar to that in dpp loss-of-function flies. Nine genes are identified as potential downstream targets of Doc in regulating thorax closure by molecular and genetic screens. Our results reveal a novel function of Doc in Drosophila development. The candidate target genes provide new clues for unravelling the mechanism of collective cell movement. |
| 巻・号 | 23(9) |
| 公開日 | 2022-4-20 |
| DOI | 10.3390/ijms23094543 |
| PII | ijms23094543 |
| PMID | 35562934 |
| PMC | PMC9104307 |
| MeSH | Animals Drosophila* / metabolism Drosophila Proteins* / metabolism Gene Expression Regulation, Developmental Pupa / genetics Pupa / metabolism Thorax Transcription Factors / metabolism |
| IF | 4.556 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#206122 |