RRC ID 70737
Author Lin CH, Senapati B, Chen WJ, Bansal S, Lin S.
Title Semaphorin 1a-mediated dendritic wiring of the Drosophila mushroom body extrinsic neurons.
Journal Proc Natl Acad Sci U S A
Abstract SignificanceThe adult Drosophila mushroom body (MB) is one of the most extensively studied neural circuits. However, how its circuit organization is established during development is unclear. In this study, we provide an initial characterization of the assembly process of the extrinsic neurons (dopaminergic neurons and MB output neurons) that target the vertical MB lobes. We probe the cellular mechanisms guiding the neurite targeting of these extrinsic neurons and demonstrate that Semaphorin 1a is required in several MB output neurons for their dendritic innervations to three specific MB lobe zones. Our study reveals several intriguing molecular and cellular principles governing assembly of the MB circuit.
Volume 119(12)
Pages e2111283119
Published 2022-3-22
DOI 10.1073/pnas.2111283119
PMID 35286204
PMC PMC8944846
MeSH Animals Dopaminergic Neurons Drosophila / physiology Mushroom Bodies* / physiology Neurites Semaphorins* / genetics
IF 9.412
Drosophila DGRC#111328