論文 - 詳細
| RRC ID | 70737 |
|---|---|
| 著者 | Lin CH, Senapati B, Chen WJ, Bansal S, Lin S. |
| タイトル | Semaphorin 1a-mediated dendritic wiring of the Drosophila mushroom body extrinsic neurons. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
SignificanceThe adult Drosophila mushroom body (MB) is one of the most extensively studied neural circuits. However, how its circuit organization is established during development is unclear. In this study, we provide an initial characterization of the assembly process of the extrinsic neurons (dopaminergic neurons and MB output neurons) that target the vertical MB lobes. We probe the cellular mechanisms guiding the neurite targeting of these extrinsic neurons and demonstrate that Semaphorin 1a is required in several MB output neurons for their dendritic innervations to three specific MB lobe zones. Our study reveals several intriguing molecular and cellular principles governing assembly of the MB circuit. |
| 巻・号 | 119(12) |
| ページ | e2111283119 |
| 公開日 | 2022-3-22 |
| DOI | 10.1073/pnas.2111283119 |
| PMID | 35286204 |
| PMC | PMC8944846 |
| MeSH | Animals Dopaminergic Neurons Drosophila / physiology Mushroom Bodies* / physiology Neurites Semaphorins* / genetics |
| IF | 9.412 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 21 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#111328 |