論文 - 詳細
| RRC ID | 70738 |
|---|---|
| 著者 | Jagannathan M, Yamashita YM. |
| タイトル | Defective Satellite DNA Clustering into Chromocenters Underlies Hybrid Incompatibility in Drosophila. |
| ジャーナル | Mol Biol Evol |
| Abstract |
Although rapid evolution of pericentromeric satellite DNA repeats is theorized to promote hybrid incompatibility (HI) (Yunis and Yasmineh 1971; Henikoff et al. 2001; Ferree and Barbash 2009; Sawamura 2012; Jagannathan and Yamashita 2017), how divergent repeats affect hybrid cells remains poorly understood. Recently, we demonstrated that sequence-specific DNA-binding proteins cluster satellite DNA from multiple chromosomes into "chromocenters," thereby bundling chromosomes to maintain the entire genome in a single nucleus (Jagannathan et al. 2018, 2019). Here, we show that ineffective clustering of divergent satellite DNA in the cells of Drosophila hybrids results in chromocenter disruption, associated micronuclei formation, and tissue atrophy. We further demonstrate that previously identified HI factors trigger chromocenter disruption and micronuclei in hybrids, linking their function to a conserved cellular process. Together, we propose a unifying framework that explains how the widely observed satellite DNA divergence between closely related species can cause reproductive isolation. |
| 巻・号 | 38(11) |
| ページ | 4977-4986 |
| 公開日 | 2021-10-27 |
| DOI | 10.1093/molbev/msab221 |
| PII | 6327694 |
| PMID | 34302471 |
| PMC | PMC8557456 |
| MeSH | Animals Chromosomes Cluster Analysis DNA, Satellite* / genetics Drosophila* / genetics Reproductive Isolation |
| IF | 11.062 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 56 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#140754 DGRC#111248 DGRC#107850 |