論文 - 詳細
| RRC ID | 70767 |
|---|---|
| 著者 | Dhakal S, Sang J, Aryal B, Lee Y. |
| タイトル | Ionotropic receptors mediate nitrogenous waste avoidance in Drosophila melanogaster. |
| ジャーナル | Commun Biol |
| Abstract |
Ammonia and its amine-containing derivatives are widely found in natural decomposition byproducts. Here, we conducted biased chemoreceptor screening to investigate the mechanisms by which different concentrations of ammonium salt, urea, and putrescine in rotten fruits affect feeding and oviposition behavior. We identified three ionotropic receptors, including the two broadly required IR25a and IR76b receptors, as well as the narrowly tuned IR51b receptor. These three IRs were fundamental in eliciting avoidance against nitrogenous waste products, which is mediated by bitter-sensing gustatory receptor neurons (GRNs). The aversion of nitrogenous wastes was evaluated by the cellular requirement by expressing Kir2.1 and behavioral recoveries of the mutants in bitter-sensing GRNs. Furthermore, by conducting electrophysiology assays, we confirmed that ammonia compounds are aversive in taste as they directly activated bitter-sensing GRNs. Therefore, our findings provide insights into the ecological roles of IRs as a means to detect and avoid toxic nitrogenous waste products in nature. |
| 巻・号 | 4(1) |
| ページ | 1281 |
| 公開日 | 2021-11-12 |
| DOI | 10.1038/s42003-021-02799-3 |
| PII | 10.1038/s42003-021-02799-3 |
| PMID | 34773080 |
| PMC | PMC8589963 |
| MeSH | Animals Avoidance Learning Chemoreceptor Cells / metabolism* Drosophila Proteins / genetics* Drosophila Proteins / metabolism Drosophila melanogaster / genetics Drosophila melanogaster / physiology* Feces / chemistry Female Ligand-Gated Ion Channels / genetics* Ligand-Gated Ion Channels / metabolism Male Receptors, Ionotropic Glutamate / genetics* Receptors, Ionotropic Glutamate / metabolism Sodium Channels / genetics* Sodium Channels / metabolism |
| IF | 4.165 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#140936 |