論文 - 詳細
| RRC ID | 70778 |
|---|---|
| 著者 | Tamada M, Shi J, Bourdot KS, Supriyatno S, Palmquist KH, Gutierrez-Ruiz OL, Zallen JA. |
| タイトル | Toll receptors remodel epithelia by directing planar-polarized Src and PI3K activity. |
| ジャーナル | Dev Cell |
| Abstract |
Toll-like receptors are essential for animal development and survival, with conserved roles in innate immunity, tissue patterning, and cell behavior. The mechanisms by which Toll receptors signal to the nucleus are well characterized, but how Toll receptors generate rapid, localized signals at the cell membrane to produce acute changes in cell polarity and behavior is not known. We show that Drosophila Toll receptors direct epithelial convergent extension by inducing planar-polarized patterns of Src and PI3-kinase (PI3K) activity. Toll receptors target Src activity to specific sites at the membrane, and Src recruits PI3K to the Toll-2 complex through tyrosine phosphorylation of the Toll-2 cytoplasmic domain. Reducing Src or PI3K activity disrupts planar-polarized myosin assembly, cell intercalation, and convergent extension, whereas constitutive Src activity promotes ectopic PI3K and myosin cortical localization. These results demonstrate that Toll receptors direct cell polarity and behavior by locally mobilizing Src and PI3K activity. |
| 巻・号 | 56(11) |
| ページ | 1589-1602.e9 |
| 公開日 | 2021-6-7 |
| DOI | 10.1016/j.devcel.2021.04.012 |
| PII | S1534-5807(21)00321-X |
| PMID | 33932332 |
| PMC | PMC8570296 |
| MeSH | Actomyosin / metabolism Animals Cell Membrane / genetics Cell Polarity / genetics Drosophila Proteins / genetics Drosophila melanogaster / genetics Drosophila melanogaster / growth & development Embryonic Development / genetics* Morphogenesis / genetics Phosphatidylinositol 3-Kinases / genetics* Toll-Like Receptors / genetics* src-Family Kinases / genetics* |
| IF | 10.092 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 12 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#109007 |