| 著者 |
Kanoh H, Iwashita S, Kuraishi T, Goto A, Fuse N, Ueno H, Nimura M, Oyama T, Tang C, Watanabe R, Hori A, Momiuchi Y, Ishikawa H, Suzuki H, Nabe K, Takagaki T, Fukuzaki M, Tong LL, Yamada S, Oshima Y, Aigaki T, Dow JAT, Davies SA, Kurata S.
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| Abstract |
The nuclear factor-kappa B (NF-κB) pathway is an evolutionarily conserved signaling pathway that plays a central role in immune responses and inflammation. Here, we show that Drosophila NF-κB signaling is activated via a pathway in parallel with the Toll receptor by receptor-type guanylate cyclase, Gyc76C. Gyc76C produces cyclic guanosine monophosphate (cGMP) and modulates NF-κB signaling through the downstream Tollreceptor components dMyd88, Pelle, Tube, and Dif/Dorsal (NF-κB). The cGMP signaling pathway comprises a membrane-localized cGMP-dependent protein kinase (cGK) called DG2 and protein phosphatase 2A (PP2A) and is crucial for host survival against Gram-positive bacterial infections in Drosophila. A membrane-bound cGK, PRKG2, also modulates NF-κB activation via PP2A in human cells, indicating that modulation of NF-κB activation in innate immunity by the cGMP signaling pathway is evolutionarily conserved.
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