論文 - 詳細
| RRC ID | 70792 |
|---|---|
| 著者 | Kanoh H, Iwashita S, Kuraishi T, Goto A, Fuse N, Ueno H, Nimura M, Oyama T, Tang C, Watanabe R, Hori A, Momiuchi Y, Ishikawa H, Suzuki H, Nabe K, Takagaki T, Fukuzaki M, Tong LL, Yamada S, Oshima Y, Aigaki T, Dow JAT, Davies SA, Kurata S. |
| タイトル | cGMP signaling pathway that modulates NF-κB activation in innate immune responses. |
| ジャーナル | iScience |
| Abstract |
The nuclear factor-kappa B (NF-κB) pathway is an evolutionarily conserved signaling pathway that plays a central role in immune responses and inflammation. Here, we show that Drosophila NF-κB signaling is activated via a pathway in parallel with the Toll receptor by receptor-type guanylate cyclase, Gyc76C. Gyc76C produces cyclic guanosine monophosphate (cGMP) and modulates NF-κB signaling through the downstream Tollreceptor components dMyd88, Pelle, Tube, and Dif/Dorsal (NF-κB). The cGMP signaling pathway comprises a membrane-localized cGMP-dependent protein kinase (cGK) called DG2 and protein phosphatase 2A (PP2A) and is crucial for host survival against Gram-positive bacterial infections in Drosophila. A membrane-bound cGK, PRKG2, also modulates NF-κB activation via PP2A in human cells, indicating that modulation of NF-κB activation in innate immunity by the cGMP signaling pathway is evolutionarily conserved. |
| 巻・号 | 24(12) |
| ページ | 103473 |
| 公開日 | 2021-12-17 |
| DOI | 10.1016/j.isci.2021.103473 |
| PII | S2589-0042(21)01444-9 |
| PMID | 34988396 |
| PMC | PMC8710550 |
| IF | 4.447 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#112982 |