論文 - 詳細
| RRC ID | 70817 |
|---|---|
| 著者 | Tomita J, Ban G, Kato YS, Kume K. |
| タイトル | Protocerebral Bridge Neurons That Regulate Sleep in Drosophila melanogaster. |
| ジャーナル | Front Neurosci |
| Abstract |
The central complex is one of the major brain regions that control sleep in Drosophila. However, the circuitry details of sleep regulation have not been elucidated yet. Here, we show a novel sleep-regulating neuronal circuit in the protocerebral bridge (PB) of the central complex. Activation of the PB interneurons labeled by the R59E08-Gal4 and the PB columnar neurons with R52B10-Gal4 promoted sleep and wakefulness, respectively. A targeted GFP reconstitution across synaptic partners (t-GRASP) analysis demonstrated synaptic contact between these two groups of sleep-regulating PB neurons. Furthermore, we found that activation of a pair of dopaminergic (DA) neurons projecting to the PB (T1 DA neurons) decreased sleep. The wake-promoting T1 DA neurons and the sleep-promoting PB interneurons formed close associations. Dopamine 2-like receptor (Dop2R) knockdown in the sleep-promoting PB interneurons increased sleep. These results indicated that the neuronal circuit in the PB, regulated by dopamine signaling, mediates sleep-wakefulness. |
| 巻・号 | 15 |
| ページ | 647117 |
| 公開日 | 2021-1-1 |
| DOI | 10.3389/fnins.2021.647117 |
| PMID | 34720844 |
| PMC | PMC8554056 |
| IF | 3.707 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#106482 DGRC#108064 |