RRC ID 70834
Author Płochocka AZ, Ramirez Moreno M, Davie AM, Bulgakova NA, Chumakova L.
Title Robustness of the microtubule network self-organization in epithelia.
Journal Elife
Abstract Robustness of biological systems is crucial for their survival, however, for many systems its origin is an open question. Here, we analyze one subcellular level system, the microtubule cytoskeleton. Microtubules self-organize into a network, along which cellular components are delivered to their biologically relevant locations. While the dynamics of individual microtubules is sensitive to the organism's environment and genetics, a similar sensitivity of the overall network would result in pathologies. Our large-scale stochastic simulations show that the self-organization of microtubule networks is robust in a wide parameter range in individual cells. We confirm this robustness in vivo on the tissue-scale using genetic manipulations of Drosophila epithelial cells. Finally, our minimal mathematical model shows that the origin of robustness is the separation of time-scales in microtubule dynamics rates. Altogether, we demonstrate that the tissue-scale self-organization of a microtubule network depends only on cell geometry and the distribution of the microtubule minus-ends.
Volume 10
Published 2021-2-1
DOI 10.7554/eLife.59529
PII 59529
PMID 33522481
PMC PMC7920549
MeSH Animals Computer Simulation Cytoskeleton* Drosophila melanogaster / growth & development Epithelial Cells / cytology Microtubules* Models, Theoretical
IF 7.08
Drosophila DGRC#109007