論文 - 詳細
| RRC ID | 70836 |
|---|---|
| 著者 | Al Hayek S, Alsawadi A, Kambris Z, Boquete JP, Bohère J, Immarigeon C, Ronsin B, Plaza S, Lemaitre B, Payre F, Osman D. |
| タイトル | Steroid-dependent switch of OvoL/Shavenbaby controls self-renewal versus differentiation of intestinal stem cells. |
| ジャーナル | EMBO J |
| Abstract |
Adult stem cells must continuously fine-tune their behavior to regenerate damaged organs and avoid tumors. While several signaling pathways are well known to regulate somatic stem cells, the underlying mechanisms remain largely unexplored. Here, we demonstrate a cell-intrinsic role for the OvoL family transcription factor, Shavenbaby (Svb), in balancing self-renewal and differentiation of Drosophila intestinal stem cells. We find that svb is a downstream target of Wnt and EGFR pathways, mediating their activity for stem cell survival and proliferation. This requires post-translational processing of Svb into a transcriptional activator, whose upregulation induces tumor-like stem cell hyperproliferation. In contrast, the unprocessed form of Svb acts as a repressor that imposes differentiation into enterocytes, and suppresses tumors induced by altered signaling. We show that the switch between Svb repressor and activator is triggered in response to systemic steroid hormone, which is produced by ovaries. Therefore, the Svb axis allows intrinsic integration of local signaling cues and inter-organ communication to adjust stem cell proliferation versus differentiation, suggesting a broad role of OvoL/Svb in adult and cancer stem cells. |
| 巻・号 | 40(4) |
| ページ | e104347 |
| 公開日 | 2021-2-15 |
| DOI | 10.15252/embj.2019104347 |
| PMID | 33372708 |
| PMC | PMC7883054 |
| MeSH | Animals Cell Differentiation* Cell Self Renewal* DNA-Binding Proteins / genetics DNA-Binding Proteins / metabolism* Drosophila Drosophila Proteins / genetics Drosophila Proteins / metabolism* Female Gene Expression Regulation, Developmental Intestines / physiology* Male Stem Cells / cytology* Stem Cells / metabolism Steroids / pharmacology* Transcription Factors / genetics Transcription Factors / metabolism* |
| IF | 9.889 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 15 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | |