RRC ID 70838
Author Sriskanthadevan-Pirahas S, Turingan MJ, Chahal JS, Thorson E, Khan S, Tinwala AQ, Grewal SS.
Title Adipose mitochondrial metabolism controls body growth by modulating systemic cytokine and insulin signaling.
Journal Cell Rep
Abstract Animals must adapt their growth to fluctuations in nutrient availability to ensure proper development. These adaptations often rely on specific nutrient-sensing tissues that control whole-body physiology through inter-organ communication. While the signaling mechanisms that underlie this communication are well studied, the contributions of metabolic alterations in nutrient-sensing tissues are less clear. Here, we show how the reprogramming of adipose mitochondria controls whole-body growth in Drosophila larvae. We find that dietary nutrients alter fat-body mitochondrial morphology to lower their bioenergetic activity, leading to rewiring of fat-body glucose metabolism. Strikingly, we find that genetic reduction of mitochondrial bioenergetics just in the fat body is sufficient to accelerate body growth and development. These growth effects are caused by inhibition of the fat-derived secreted peptides ImpL2 and tumor necrosis factor alpha (TNF-α)/Eiger, leading to enhanced systemic insulin signaling. Our work reveals how reprogramming of mitochondrial metabolism in one nutrient-sensing tissue can couple nutrient availability to whole-body growth.
Volume 39(6)
Pages 110802
Published 2022-5-10
DOI 10.1016/j.celrep.2022.110802
PII S2211-1247(22)00569-1
PMID 35545043
MeSH Adipose Tissue / metabolism Animals Cytokines / metabolism Drosophila / metabolism Drosophila Proteins* / metabolism Energy Metabolism Insulin* / metabolism Insulin-Like Growth Factor Binding Proteins / metabolism Mitochondria / metabolism
IF 8.109
Drosophila 4217R-3