論文 - 詳細
| RRC ID | 70854 |
|---|---|
| 著者 | Sainz de la Maza D, Hof-Michel S, Phillimore L, Bökel C, Amoyel M. |
| タイトル | Cell-cycle exit and stem cell differentiation are coupled through regulation of mitochondrial activity in the Drosophila testis. |
| ジャーナル | Cell Rep |
| Abstract |
Whereas stem and progenitor cells proliferate to maintain tissue homeostasis, fully differentiated cells exit the cell cycle. How cell identity and cell-cycle state are coordinated during differentiation is still poorly understood. The Drosophila testis niche supports germline stem cells and somatic cyst stem cells (CySCs). CySCs give rise to post-mitotic cyst cells, providing a tractable model to study the links between stem cell identity and proliferation. We show that, while cell-cycle progression is required for CySC self-renewal, the E2f1/Dp transcription factor is dispensable for self-renewal but instead must be silenced by the Drosophila retinoblastoma homolog, Rbf, to permit differentiation. Continued E2f1/Dp activity inhibits the expression of genes important for mitochondrial activity. Furthermore, promoting mitochondrial biogenesis rescues the differentiation of CySCs with ectopic E2f1/Dp activity but not their cell-cycle exit. In sum, E2f1/Dp coordinates cell-cycle progression with stem cell identity by regulating the metabolic state of CySCs. |
| 巻・号 | 39(6) |
| ページ | 110774 |
| 公開日 | 2022-5-10 |
| DOI | 10.1016/j.celrep.2022.110774 |
| PII | S2211-1247(22)00538-1 |
| PMID | 35545055 |
| PMC | PMC9350557 |
| MeSH | Animals Cell Cycle Cell Differentiation / genetics Cysts* / metabolism Drosophila / metabolism Drosophila Proteins* / genetics Drosophila Proteins* / metabolism Drosophila melanogaster / metabolism Male Retinoblastoma Protein / metabolism Stem Cell Niche / genetics Testis Transcription Factors / metabolism |
| IF | 8.109 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 35 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#115279 |