論文 - 詳細
| RRC ID | 70896 |
|---|---|
| 著者 | Shimizu M, Miyanaga A, Seike M, Matsuda K, Matsumoto M, Noro R, Fujita K, Mano Y, Furuya N, Kubota K, Gemma A. |
| タイトル | The respiratory microbiome associated with chronic obstructive pulmonary disease comorbidity in non-small cell lung cancer. |
| ジャーナル | Thorac Cancer |
| Abstract |
BACKGROUND:Research has shown that some microbiomes are linked to cancer. Hence, we hypothesize that alterations in the respiratory microbiome might be associated with lung cancer. METHODS:Through droplet digital polymerase chain reaction analysis, we investigated the abundance of Acidovorax in surgically resected primary tumors and corresponding nontumor lung tissues obtained from 50 Japanese patients with non-small cell lung cancer. RESULTS:The rate of positivity for Acidovorax in tumor and nontumor tissues was 44 and 26%, respectively. The abundance of Acidovorax in tumor tissues was significantly higher in patients with nonsquamous cell carcinoma complicated by chronic obstructive pulmonary disease (COPD) and those who relapsed after surgical resection (p < 0.05). In tumor tissues, the results of the univariate and multivariate analyses revealed that only COPD exerted a direct effect on the abundance of Acidovorax (p < 0.05). Furthermore, the presence of Acidovorax was high in lung cancer patients with COPD comorbidity (65%) and TP53 gene mutation; only one of the nontumor tissues was positive for Acidovorax. In patients with lung cancer complicated by COPD, Acidovorax tended to be present in both the tumor and nontumor areas. CONCLUSIONS:This study identified novel microbiota involved in lung cancer with COPD comorbidity. The results suggested that Acidovorax may be a useful biomarker in the screening for lung cancer. Further studies are warranted to validate the clinical significance of the microbiome in a larger independent patient cohort. |
| 巻・号 | 13(13) |
| ページ | 1940-1947 |
| 公開日 | 2022-7-1 |
| DOI | 10.1111/1759-7714.14463 |
| PMID | 35580613 |
| PMC | PMC9250845 |
| MeSH | Carcinoma, Non-Small-Cell Lung* / complications Carcinoma, Non-Small-Cell Lung* / epidemiology Carcinoma, Non-Small-Cell Lung* / surgery Comorbidity Humans Lung Neoplasms* / complications Lung Neoplasms* / epidemiology Lung Neoplasms* / genetics Microbiota* / genetics Pulmonary Disease, Chronic Obstructive* / complications Pulmonary Disease, Chronic Obstructive* / epidemiology |
| IF | 2.524 |
| リソース情報 | |
| ヒト・動物細胞 | HFL-I(RCB0521) |