論文 - 詳細
| RRC ID | 71004 |
|---|---|
| 著者 | Hirose M, Yoshida Y, Horii K, Hasegawa Y, Shibuya Y. |
| タイトル | Efficacy of antimicrobial photodynamic therapy with Rose Bengal and blue light against cariogenic bacteria. |
| ジャーナル | Arch Oral Biol |
| Abstract |
OBJECTIVE:We evaluated the effect of antimicrobial photodynamic therapy (a-PDT) with Rose Bengal and blue light LED on bacteria that initiate and promote dental caries. DESIGN:Colony forming units of Streptococcus mutans, Streptococcus sobrinus, Streptococcus sanguinis, and Lactobacillus salivarius under planktonic and biofilm conditions were counted after a-PDT treatment using Rose Bengal and blue light LED. In addition, cariogenic bacteria from saliva and dental plaques from ten volunteers were used for evaluation of a-PDT treatment. RESULTS:We found that a-PDT using Rose Bengal at > 10 μg/mL had antimicrobial effects on oral Gram-positive S. mutans, S. sobrinus, S. sanguinis, and L. salivarius under both planktonic and biofilm conditions. The effect was also observed for cariogenic bacteria that formed biofilms containing water-insoluble glucans, through which the bacteria are firmly attached to the tooth surface. Moreover, a-PDT led to a marked reduction in cariogenic bacteria in saliva and dental plaques. CONCLUSION:a-PDT could be a useful approach for controlling dental caries in dental surgery. |
| 巻・号 | 122 |
| ページ | 105024 |
| 公開日 | 2021-2-1 |
| DOI | 10.1016/j.archoralbio.2020.105024 |
| PII | S0003-9969(20)30402-7 |
| PMID | 33352361 |
| MeSH | Anti-Infective Agents* / pharmacology Biofilms / drug effects Biofilms / radiation effects Dental Caries / drug therapy Humans Photochemotherapy* Rose Bengal / pharmacology* Streptococcus mutans / drug effects* Streptococcus mutans / radiation effects* |
| リソース情報 | |
| 一般微生物 | JCM1040 |